I work as an honorary consultant in the Integrated Newcastle Liaison Psychiatry Team. My clinical and academic interests are influenced both by my clinical and laboratory based educational and research background. I am driven by the objective of improving clinical outcomes from molecular and cellular discoveries, to the benefit of the patient. These include:
1. Ethiopathogenesis of dementia and ageing in (i) clinical practice (neuropharmacology of cognitive impairment and behavioral problems in neurodegenerative diseases, delirium and depression in older people with medical problems) and (ii) teaching old age psychiatry and medicine to undergraduate and postgraduate students, trainees and professionals.
2. Relating this knowledge to further neuropathological and neuobiochemical knowledge of ageing in neurodevelopmental disorders, such as ageing and neurodegeneration in Down syndrome and autism.
3. Understanding the molecular substrates underlying age-associated cognitive impairment in elderly, and how they are related to the development of the 2 major neurodegenerative diseases, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB).
4. Developing biomarkers with high sensitivity and specificity to detect various forms of dementia, and their implementation in routine clinical setting with an aim to monitor the progression of the disease and treatment.